Overcoming Challenges in Large Lesions with Targeted Flow Redistribution
Supporting Visualization and Therapeutic Uptake
Precise Navigation Through Complex Vascular Anatomy
Utilizing the pressure gradient effect, the Occlusafe™ Temporary Occlusion Balloon Microcatheter offers the ability with Balloon-TACE to redistribute blood flow toward the microcirculation.
This mechanism allows for a potential increase in therapeutic accumulation at the target lesion and reduced off target embolization, potentially improving clinical outcomes in challenging lesions.
Overcoming Challenges in Large Lesions with Targeted Flow Redistribution
Lesions larger than 3 cm in diameter may achieve lower complete response rates following initial TACE treatment due to limited uptake of embolic agents. Achieving a complete response often requires multiple or combined treatment sessions2,3.
Occlusafe™ Temporary Occlusion Balloon Microcatheter induce a Pressure Gradient Effect to redistribute blood flow and access the microcirculation.
This approach enhances the concentration of therapeutics within the lesion1—an effect which might be particularly crucial for large hepatocellular carcinoma (HCC) lesions—while minimizing off-target embolisation4, and potentially supporting improved clinical outcomes5-7.
Supporting Visualisation and Therapeutic Uptake
Balloon-TACE with the Occlusafe™ Temporary Occlusion Balloon Microcatheter improves visualization of target vessels to support a more accurate diagnosis and intervention planning. Additionally, it drives higher uptake of embolic agents into the lesion1, potentially enhancing therapeutic effectiveness.
Image illustrating therapeutic distribution during TACE using a standard microcatheter (left) and using OcclusafeTM (right).
Precise Navigation Through Complex Vascular Anatomy
When using the Occlusafe™ Temporary Occlusion Balloon Microcatheter for Balloon TACE several clinical advantages over a standard microcatheter can be expected:
Improved Tumour Response5-7:
potentially driven by increased intratumoral treatment deposition.
Improved Clinical Outcomes5-7:
Targeted delivery of chemoembolic agents may contribute to more effective overall treatment results.
Enhanced Diagnostic Accuracy3:
Balloon occlusion improves vessel visualization, potentially enabling more precise lesion evaluation and procedural planning.
Protection Against Reflux9:
Temporary vessel occlusion is thought to decrease the backflow of embolic material, thus potentially improving procedural safety.
Are you ready to take TACE to the next level ?
References
Disclaimer
Not all products are available for sale in all countries. This information is provided only in respect to markets where these products are approved or cleared. All products are not cleared or approved in the U.S.A. by the Food and Drug Administration. Please contact your Terumo local sales representative for more information.
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