MASTER DAPT Study

MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus standard DAPT regimen.

Featured products: Ultimaster™ Tansei™ Sirolimus Eluting Coronary Stent System, Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System

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About MASTER DAPT Study

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MASTER DAPT is the largest multi-center randomized controlled study on the use of short duration of dual antiplatelet therapy (DAPT) in high bleeding risk patients following stenting procedures with Ultimaster™/Ultimaster™Tansei^TM drug-eluting bioresorbable polymer stents (DES).

MASTER DAPT study is sponsored by the European Cardiovascular Research Institute (ECRI, Rotterdam, The Netherlands) and supported with a restricted research grant by Terumo Europe. The study is managed by global CROs and data management group (CERC, Paris, France, Cardialysis, Rotterdam, The Netherlands, CV quest. Co. Ltd., Tokyo, Japan and CTU, Bern, Switzerland).

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MASTER DAPT Study Highlights

MASTER DAPT Study Design - A true randomized DAPT study

MASTER DAPT has met the three coprimary endpoints

1-month DAPT after implantation of Ultimaster™ family DES does not increase the ischemic risk, but reduces the bleeding risk in high bleeding risk patients
Patients with acute coronary syndrome, and patients who underwent complex or multivessel PCI were included
Supports reduction of DAPT duration to 1 month after implantation of Ultimaster™ family DES in a broad cohort of high-bleeding risk patients
MASTER DAPT included patients at high bleeding risk who had undergone implantation of Ultimaster™ family stent; Results may not extend to patients who are not at high bleeding risk or who receive other stent types.

Abbreviated DAPT non-inferior to standard DAPT in terms of NACE

Net adverse clinical events (NACE, a composite of death from any cause, myocardial infarction, stroke, or major bleeding)*

Abbreviated DAPT non-inferior to standard DAPT in terms of MACCE

Major adverse cardiac and cerebral events* (MACCE, a composite of death from any cause, myocardial infarction, or stroke)

Abbreviated DAPT superior to standard DAPT in terms of bleeding

Major or clinically relevant non-major bleeding* (MCB)

Download the Master Dapt Total Population Clinical Summary

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Publications on MASTER DAPT

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk. Marco Valgimigli, M.D., Ph.D et al. The New England Journal of Medicine, August 28, 2021, DOI: 10.1056/NEJMoa2108749

Abbreviated Antiplatelet Therapy in Patients at High Bleeding Risk With or Without Oral Anticoagulant Therapy After Coronary Stenting: An Open-Label, Randomized, Controlled Trial. Pieter C. Smits et al. Circulation, August 29, 2021, 10.1161/CIRCULATIONAHA.121.056680

Abbreviated Antiplatelet Therapy After Coronary Stenting in Patients With Myocardial Infarction at High Bleeding Risk. Smits P, Frigoli E, Vranckx P, et al. J Am Coll Cardiol. 2022 Sep, 80 (13) 1220–1237

Duration of antiplatelet therapy after complex percutaneous coronary intervention in patients at high bleeding risk: a MASTER DAPT trial sub-analysis. Marco Valgimigli, M.D., Ph.D et al. European Heart Journal, September 1, 2022, DOI: 10.1093/eurheartj/ehac284

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