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The investigator-initiated MASTER DAPT study demonstrates that one month of DAPT was non-inferior to treatment continuation for at least 2 additional months for the occurrence of net and major adverse clinical events, and reduced major or clinically relevant non-major bleeding.

MASTER DAPT, the largest multi-center randomized controlled study on the use of short duration of dual antiplatelet therapy (DAPT) in high bleeding risk patients following stenting procedures with Ultimaster™/Ultimaster™TanseiTM drug-eluting bioresorbable polymer stents (DES). 

A total cohort of 4.579 patients have been randomized into this ambitious study.

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The UltimasterTM Clinical Program included one of the largest, prospective worldwide registries, the e- ULTIMASTER™ with 37,198 patients. The Ultimaster™ Clinical Program² demonstrates the safe and effective use of the Ultimaster stent in different patient cohorts, representative of daily PCI practice. 

Total Population
  • 37,178 patients enrolled in the e-ULTIMASTER™ registry, one of the largest, prospective worldwide registries.
  • e-ULTIMASTER™– a truly all comer's DES clinical registry.
Complex PCI
  • e-ULTIMASTER™ all-comer registry enrolled more than 10,000 patients meeting complex PCI criteria.
  • Complex PCI was defined as:
    - Multivessel PCI > 3 stents implanted > 3 lesions treated.
    - Bifurcation PCI with > 2 stents, total stent length > 60mm and chronic total occlusion.
  • 4,395 patients with bifurcation lesions treated with Ultimaster™ DES showed excellent clinical outcomes with TLF of 5.1% at 1 year. 
  • Use of the proximal optimization technique (POT) was associated with a better clinical outcome with respect to TLF and TVF at 1 year. This was due to a strong impact on the risk of TV-MI, stent thrombosis and revascularisation.
Multivessel Disease
  • The revascularization strategy (complete versus incomplete revascularization) in multivessel disease patients treated with Ultimaster™ DES was assessed at 1-year follow-up.
  • Complete revascularization was associated with better relief from angina, lower mortality, less target vessel failure (TVF), and lower patient oriented composite endpoint (POCE).
  • Ultimaster™ DES demonstrated excellent results in this complex population.

Largest study to date on 1-year outcomes post-PCI, in an unselected, real-world cohort of patients enrolled in the e-ULTIMASTER registry.

The aim of the study was to understand the prevalence, clinical characteristics, and 1-year outcomes of patients with complex lesions in an unselected cohort of over 35,000 patients who underwent PCI with the Ultimaster™ DES system.”

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