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What is the great innovation of LifePearl?2

  1. Hydrogel technology based formulation:
    The innovation of LifePearl is that Polyethylene Glycol (PEG) guarantees more compressibility, elasticity and maximizes the microspheres' suspension time while making the pearls more resilient to stress and attrition.1

    What are the benefits of PEG?3
    • Hydrophilic material > allows better compressibility, elasticity and catheter deliverability
    • Addition of SPAc (sulfonate bonding) guarantees that LifePearl increases the drug retention and release inside the liver

      Less than 1% of the microspheres showed any observable damage in standard attrition testing.

  2. Tight calibration3
    • Precise embolization, which allows less risk of non-target chemoembolization
    • Precise calibration (100, 200, 400 μm sizes)
    • Excellent compressibility
    • Good resilience means less than 1% sub sized embolic particles

       
  3. Enhanced suspension characteristics4
    PEG material minimizes time to suspension while maximizing time in suspension.

    Drug-loaded LifePearl stays in suspension for longer

  4. Syringe presentation
    Easy-to-use format: Delivered with color-coded labels for easy use and identification
Read more Read less
Volume of microspheres2 ml
Volume of PBS4 ml

 

Comparison of loading times with Irinotecan & Doxorubicin5

LifePearl sizes​75 mg liquid Doxorubicin per 2 ml of microspheres75 mg powder​ Doxorubicin per 2 ml of microspheres​100 mg Irinotecan solution per 2 ml of microspheres

​100 ± 25 µm

​1 hour​30 minutes30 minutes​
​200 ± 50 µm​4 hours​30 minutes​30 minutes
​400 ± 50 µm​6 hours30 minutes​​30 minutes
LifePearl sizesColourItem reference
100 ± 25 μmBlack8LP2S100
200 ± 50 μmYellow8LP2S200
400 ± 50 μmBlue8LP2S400

Please quote above item reference codes when placing an order.

 

 

An In Vitro Evaluation of Four Types of Drug-Eluting Microspheres Loaded with Doxorubicinhttps://www.terumo-europe.com/en-emea/clinicaldata/an-in-vitro-evaluation-of-four-types-of-drug-eluting-microspheres-loaded-with-doxorubicinAn In Vitro Evaluation of Four Types of Drug-Eluting Microspheres Loaded with Doxorubicin<p>​​de Baere T, Plotkin S, Yu R, Sutter A, Wu Y, Cruise GM, <span lang="EN-US">J Vasc Interv Radiol<span style="text-decoration:underline;">.</span></span> 2016 Sep;27(9):1425-31. doi: 10.1016/j.jvir.2016.05.015. Epub 2016 Jul 9.</p>HayabusaArticlePage
An In Vitro Evaluation of Three Types of Drug-Eluting Microspheres Loaded with Irinotecanhttps://www.terumo-europe.com/en-emea/clinicaldata/an-in-vitro-evaluation-of-three-types-of-drug-eluting-microspheres-loaded-with-irinotecanAn In Vitro Evaluation of Three Types of Drug-Eluting Microspheres Loaded with Irinotecan<p>​Pereira, P.L.; Plotkin, S.; Yu, R.; Sutter, A.; Wu, Y.; Sommer, C.M.; Cruise, G.M., Anti-Cancer Drugs: October 2016 - Volume 27 - Issue 9 - p 873–878. </p>HayabusaArticlePage
Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapyhttps://www.terumo-europe.com/en-emea/clinicaldata/hepatic-arterial-infusion-of-polyethylene-glycol-drug-eluting-beads-for-primary-and-metastatic-liver-cancer-therapyHepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapy<p>​​<span lang="IT">Aliberti C</span>, <span lang="IT">Carandina R</span>, <span lang="IT">Sarti D</span>, <span lang="IT">Mulazzani L</span>, <span lang="IT">Catalano V</span>, <span lang="IT">Felicioli A</span>, <span lang="IT">Coschiera P</span>, <span lang="IT">Fiorentini G, <span lang="EN-US">Anticancer Res.</span> 2016 Jul;36(7):3515-21.</span></p>HayabusaArticlePage

 

 

 

 

 

 

LifePearl loading instructions Doxorubicin (Liquid)https://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Doxorubicin (Liquid).pdfLifePearl loading instructions Doxorubicin (Liquid)19/10/2016 22:00:00{72886611-F7F3-4EE9-A07E-20DBE5713A06}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions Irinotecanhttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Irinotecan.pdfLifePearl loading instructions Irinotecan19/10/2016 22:00:00{8F5CA745-8EBE-47D8-833C-007A3D9C5B2D}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions Doxorubicin (Powder)https://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Doxorubicin (Powder).pdfLifePearl loading instructions Doxorubicin (Powder)19/10/2016 22:00:00{5E4DB38A-E996-4989-91F9-DD66C44D4BA2}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8

LifePearl is not available for sale in all countries. This information is provided only in respect to markets where this product is approved or cleared.  LifePearl is cleared in US with indications for embolization of hyper vascular tumors and arteriovenous malformations. LifePearl is not approved in Canada. Please contact your Terumo local sales representative for more information.

 

1 Data on file. Comparison with Terumo's previously commercialized product. Ref LPMCV-004
2 Camillo Aliberti, et al. Transarterial Chemoembolization using Polyethylene Glycol drug-eluting beads pre-charged with doxorubicin (LIFDOX®) for the treatment of Primary liver cancer: preliminary results. Anticancer Res. 2016 Jul;36(7):3515-21.
3 Data on file. Ref LPBTG-002, LPMCV-003, LPMCV-004. Microvention Inc. Comparison with Terumo's previously commercialized product
4 Data on file. Ref. LPMCV-004. Microvention Inc. Comparison with Terumo's previously commercialized product.
5 Data on file. Ref TR14-286 Microvention Inc. Comparison with Terumo's previously commercialized product

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