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​Our Drug-Eluting Microspheres Portfolio includes: 

  • LifePearl™ microspheres have specific features that offer value in DEM-TACE procedures. Veloso et al2 reported results from one of the largest multicentric cohorts of unresectable HCC patients (n=580) treated with LifePearl™ microspheres to date with over 4 years Median OS (50.8 months [95% CI 44.7–NE]) and 60.1% complete response rate exceeding what is reported in previous studies.3,4,5
  • Biopearl™ microspheres are our latest innovation in TACE treatment :
    • First resorbable drug-eluting microspheres
    • Progressive blood flow restoration6
    • Sustained chemotherapeutic drug release (in-vitro)7
    • Embolic effect6

​The Holmium Platform delivers a first in SIRT: a comprehensive end-to-end platform for treating unresectable liver tumours.
The Holmium Platform consists of three integrated products that allow you to select patients with confidence, deliver treatment with precision, and plan and verify with accuracy.
The Holmium Platform: delivering Individualized Treatment to the right Patient.​

​​TATO (Thermal Ablation Treatments for Oncology) is a 2.450 Mhz Microwave Thermal Ablation System that allows you to enhance the visibility and control on your ablation procedures, using up to 4 antennas simultaneously. Individualize the HCC treatment in open surgery, percutaneous or laparoscopic approach by choosing among 11G, 14G, 17G, and 18G antennas in various lengths. Choose a combination of a number of antennas, gauge, time, and power applied, to achieve from very small to very large ablation areas. The low presence of artifacts and gas bubbles allows to see vital structures and ablation progression under ultrasound guidance8, to approach challenging locations with confidence.

Progreat™ Micro Catheter System, Progreat Lambda™ Microcatheter System and RADIFOCUS Guide Wire GT with gold coil are Terumo legacy​ solutions for a precise and selective access to target lesions, designed for uncompromised navigability9 and controlled therapeutic embolization.


Occlusafe™ Temporary Occlusion Balloon Microcatheter​ is a balloon-microcatheter which allows a local flow redistribution, resulting in an high-density accumulation of the therapeutics into the target lesion10 and in a reduced non-target  embolization.11

  1. De Baere T et al. J Vasc Interv Radiol 2016;27:1425–31 
  2. Veloso Gomes et al Cardiovasc Intervent Radiol 46, pages 436–446 (2023) 
  3. Meyer T, et al. Lancet Gastroenterol Hepatol. 2017 
  4. Kudo M, et al. Gut. 2020 
  5. Lencioni R, et al. J Hepatology. 2016436–446 (2023) 
  6. Data on file: TR18-174B – BioPearl™ Liver studies 
  7. Data on file: JRD20-0122​
  8. hep-2022-0002 - Eduardo Crespo liver ablation 
  9. Bench testing done by Terumo Corporation. Data on file (TC-Pro107). Bench test data may not necessarily be indicative of clinical performance 
  10. Toshiyuki I et al. Cardiovasc. Intervent Radiol. 2013; 36(3):706-7​13​
  11. Tomohiro M et al. Minim Invasive Ther Allied Technol. 2015; 24(2​):94-100

What the evidence says

Discover our clinical evidence and case studies concerning this topic.

Long-Term Outcomes of Balloon TACE for HCC: An European Multicentre Single-Arm Retrospective Study

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Percutaneous thermal segmentectomy for liver malignancies over 3 cm: mid-term oncological performance and predictors of sustained complete response from a multicentric Italian retrospective study

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Transarterial chemoembolization with anthracyclines-loaded polyethylene glycol drug eluting microspheres for the treatment of hepatocellular carcinoma: A pooled multicentric analysis of survival in 580 patients

Featured product: LifePearl™ Drug Elutable Microspheres

MW ablation of Lung metastasis

Featured product: TATO Thermal Ablation Treatments for Oncology

Local remnant of renal cell carcinoma treated with CT guided microwave ablation

Featured product: TATO Thermal Ablation Treatments for Oncology

Recurrence of renal cell carcinoma treated with microwave ablation

Featured product: TATO Thermal Ablation Treatments for Oncology

TATO 17G MW Antenna treatment of an adrenal gland colorectal cancer metastasis

Featured product: TATO Thermal Ablation Treatments for Oncology

Renal cell carcinoma treated with microwave ablation

Featured product: TATO Thermal Ablation Treatments for Oncology

Challenging Lesion - White Paper

Featured product: TATO Thermal Ablation Treatments for Oncology

Balloon-Occluded Transarterial Chemoembolization: In which size range does it perform best? A comparison of its efficacy versus conventional Transarterial Chemoembolization, using Propensity score matching

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Balloon occluded TACE (B-TACE) vs DEM-TACE for HCC: a single center retrospective case control study

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Balloon-Occluded Transcatheter Arterial Chemoembolization (b-TACE) for Hepatocellular Carcinoma Performed with Polyethylene-Glycol Epirubicin-Loaded Drug-Eluting Embolics: Safety and Preliminary Results

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Balloon-occluded chemoembolization for hepatocellular carcinoma: a prospective study of safety, feasibility and outcomes

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Retrospective European Multicentric Evaluation of Selective Transarterial Chemoembolisation with and without Balloon-Occlusion in Patients with Hepatocellular Carcinoma: A Propensity Score Matched Analysis

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

Chemoembolization of Hepatocellular Carcinoma with Drug-Eluting Polyethylene Glycol Embolic Agents: Single-Center Retrospective Analysis in 302 Patients

Featured product: LifePearl™ Drug Elutable Microspheres

Chemoembolization Alone or Associated with Bevacizumab for Therapy of Colorectal Cancer Metastases: Preliminary Results of a Randomized Study

Featured product: LifePearl™ Drug Elutable Microspheres

LifePearl microspheres loaded with irinotecan in the treatment of Liver-dominant metastatic colorectal carcinoma: feasibility, safety and pharmacokinetic study

Featured product: LifePearl™ Drug Elutable Microspheres

Polyethylene Glycol Epirubicin-Loaded Transcatheter Arterial Chemoembolization Procedures Utilizing a Combined Approach with 100 and 200 μm Microspheres: A Promising Alternative to Current Standards

Featured product: LifePearl™ Drug Elutable Microspheres

Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer

Featured product: LifePearl™ Drug Elutable Microspheres

Real Life Prospective Evaluation of New Drug-Eluting Platform for Chemoembolization of Patients with Hepatocellular Carcinoma: PARIS Registry

Featured product: LifePearl™ Drug Elutable Microspheres

Safety, tolerability, and efficacy of transarterial chemoembolization using anthracyclines-loaded drug-eluting microspheres for treatment of patients with unresectable hepatocellular carcinoma: Pooled analyses

Featured product: LifePearl™ Drug Elutable Microspheres

The CIREL Cohort: A Prospective Controlled Registry Studying the Real-Life Use of Irinotecan-Loaded Chemoembolization in Colorectal Cancer Liver Metastases: Interim Analysis

Featured product: LifePearl™ Drug Elutable Microspheres

Advanced TACE Programme Studies

Featured products: LifePearl™ Drug Elutable Microspheres, Occlusafe™ Temporary Occlusion Balloon Microcatheter

The Holmium Platform

Featured products: QuiremScout™ Microspheres, QuiremSpheres™ Microspheres

Safety Analysis of Holmium-166 Microsphere Scout Dose Imaging During Radioembolisation Work-Up: A Cohort Study

Featured product: QuiremScout™ Microspheres

Holmium-166 Radioembolisation in Hepatocellular Carcinoma: Feasibility and Safety of a New Treatment Option in Clinical Practice

Featured product: QuiremSpheres™ Microspheres

Efficacy of Radioembolisation with 166 Ho-Microspheres in Salvage Patients with Liver Metastases: A Phase 2 Study

Featured product: QuiremSpheres™ Microspheres

Holmium-166 Radioembolisation in Patients with Unresectable, Chemorefractory Liver Metastases (HEPAR trial): A phase 1, Dose-Escalation Study

Featured product: QuiremSpheres™ Microspheres

First evidence for a dose-response relationship in patients treated with 166Ho-radioembolization: a prospective study

Featured product: QuiremSpheres™ Microspheres

Quality of life in patients with liver tumors treated with holmium‑166 radioembolization

Featured product: QuiremSpheres™ Microspheres

The superior predictive value of 166Ho-scout compared with 99mTc-macroaggregated albumin prior to 166Ho-microspheres radioembolization in patients with liver metastases

Featured product: QuiremScout™ Microspheres

Clinical experience of QuiremScout® in a 69-year-old female patient with intrahepatic cholangiocarcinoma (iCCA)

Featured product: QuiremScout™ Microspheres

Clinical use of QuiremScout® in a 55-year-old male patient with hepatocellular carcinoma (HCC)

Featured product: QuiremScout™ Microspheres

Balloon-Occluded Transcatheter Arterial Chemoembolization (b- TACE) for Hepatocellular Carcinoma Performed with Polyethylene-Glycol Epirubicin-Loaded Drug-Eluting Embolics: Safety and Preliminary Results

Featured product: Occlusafe™ Temporary Occlusion Balloon Microcatheter

See all clinical evidence

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