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​The Holmium Platform: 
Delivering Individualized Treatment to the Right Patient

The Holmium Platform delivers a first in SIRT: a comprehensive end to end platform for treating unresectable liver tumours.

The Holmium Platform consists of three integrated products that allow you to select patients with confidence, deliver treatment with precision ad plan and verify with accuracy.

QuiremScout™: The first SIRT work-up product that uses the same technology as the therapeutic microspheres, to optimize patient selection and advance treatment planning

Quiremspheres™: The only therapeutic SIRT microsphere that is used as part of a fully integrated platform, to improve patient outcomes and advance the future of SIRT


  • Dedicated Holmium-166 software for individualized treatment planning
  • Accurate post treatment dosimetry to verify the radiation dose delivered


  • ​​​​SIRT with the Holmium Platform

    ​QuiremSpheres™ and QuiremScout™ consist of Holmium-166 microspheres that offer unique imaging capabilities

    ​Q-SuiteTM: dedicated holmium-166 software for individualized treatment planning:

    • Treatment Activity Planning as recommended in QuiremSpheres™ instructions for use
    • Lung Dose Prediction based on SPECT after QuiremScout™ and/or Tc-99mMAA
    • Pre-Treatment Dose Simulation - multi-compartment treatment planning based on QuiremScout™ and/or Tc-99mMAA
  • ​​​Innovation with Holmium

    ​The short half life of Holmium-166 in QuiremSpheres™ ensures delivery of a high dose rate (90% of radiotherapy dose delivered within 4 days)

  • ​​Clinical evidence and treatment

    ​​​Clinical evidence demonstrates that QuiremSpheres™ are efficacious (1) well tolerated (2) and safe (1-3) for the treatment of unresectable liver cancer.

    “With QuiremSpheres™ we see the majority of our patients responding much quicker than what we are used to seeing with Yttrium-90”  Dr. Irene Bargellini, Head of Radiology, Cuneo Hospital

  • Post-treatment Visualization and Quantification

    ​Holmium-166 microspheres allow for post-treatment visualization and quantification using MRI and SPECT, for further analysis in  Q-SuiteTM

    QuiremSpheres™ gives us the confidence we need to start individualizing treatments
    Prof. Dr. Ralf-Thorsten Hoffmann, Head of Interventional Radiology, University Hospital Dresden

  • ​Q-SuiteTM

    Q-SuiteTM: accurate post-treatment dosimetry to verify the radiation dose delivered

    • Dose Reconstruction based on quantitative Holmium-166 MRI or SPECT
    • Evaluation of Dose absorbed in tumour and in healthy liver tissue

​Deliver with ease

QuiremSpheres® and QuiremScout® use the same intuitive and efficient administration system
The system is easy to learn – it has been developed in collaboration with leading SIRT physicians and incorporates features that you may already be familiar with if you have performed SIRT.


Video instructions



Clinical evidence

See all clinical evidence

General specifications

​QuiremSpheresTM is supplied as a standard dose in a single capped V-vial or as a standard dose divided among several capped V-vials.

QuiremSpheresTMOther SIRT products
Beta-radiation (Emax)1.77 MeV (48.7%)
1.85 MeV (50.0%)
2.28 MeV
Gamma-radiation81 keV (6.7%)-
Visible on MRIYesNo
Half-life26.8 hours64.1 hours
MaterialPoly(L-lactic acid)Resin (r) or glass (g)
Diameter15-60 μm20-60 μm (r) 
20-30 μm (g)
Density1.4 g/cm31.6 g/cm3 (r) 
3.3 g/cm3 (g)

​Software Requirements
​Hardware Recommendations
  • ​x64 based computer running Microsoft Windows 7, 8.1 or 10
  • ​Dual-core CPU, 2.0GHz or higher
  • 16 GB RAM
  • SSD with 20 GB free disk space
  • Screen resolution 1920x1080 or higher

Item specifications

Item reference
​Material description
​QS-V001​Holmium-166 microspheres,QuiremSpheres™
​V-vial containing a patient-specific dose of QuiremSpheres™
QS-C001​Customer kit
​Set of re-usable administration box and accessories for administration of QuiremSpheres™
QS-D001​Delivery setSet of sterile single-use tube lines for administration of QuiremSpheres™ (in a carton of 6 pieces)​

​Item reference
​Material description
​Holmium 166 SIRT planning & post-treatment verification software

​QuiremSpheres™ is a product manufactured by Quirem Medical B.V. and has CE-mark.

QuiremSpheres™ is not available for sale in all countries. This information is provided only in respect to markets where the product is approved or cleared. QuiremSpheres™ is not FDA cleared in the US for sale.

QuiremSpheres™ is not approved in Canada


Relevant product information
The Holmium Platform


1 HEPAR I: Smits et al, 2012 Lancet Oncology 
2 HEPAR II: Prince et al, 2017 Journal of Nuclear Medicine

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