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TCD-10023PK Trial

31/05/2013 -  

20 patients, single arm, pharmocokinetics. PCR 2013.



1. Sirolimus Concentration

Very low concentration of drug in peripheral circulation

TCD-10023PK - Primary Endpoint

2. Preserved endothelial function in stented human coronary arteries

TCD-10023PK - Target Lesion Failure

Vasomotor pattern of target and reference vessels at baseline, maximal atrial pacing and after nitrates given in the vessel segment distal to the study stent.

Stojkovic et al. Fundam Clin Pharmacol. 2014 Sep 16. doi: 10.1111/fcp.12092. [Epub ahead of print]