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At the time of publication, scarse evidence was available for B-TACE vs TACE, hence the authors reported data from a single center retrospective experience.
To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (B-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC).
mRECIST oncological response at all time points (1, 3–6 and 9–12 months) for both treatments were similar, except Objective response rate at 9-12 months.
Objective response at 1 and 3–6 months between B-TACE vs DEM-TACE [23/35 (65.7%) vs 119/191 (62.3%), 21/29 (72.4%) vs 78/136 (57.4%)].
On the contrary, at 9–12 months, it was significantly higher in B-TACE subgroup than DEM-TACE (15/19 [78.9%] vs 48/89 [53.9%]).
The median follow-up time was 143 days, which is higher in B-TACE comparing with DEM-TACE.
TTR for complete response at 1 year had a better trend for B-TACE vs DEM-TACE (278.0 days [196.0– 342.0] vs 219.0 days [161.0–238.0], OR 0.68 [0.4–1.0).
The use of balloon micro-catheter reduced the relative risk of the event of recurrence by 0.63 [CI95% 0.38–1.04]).
No significant differences were found in AEs rate.
B-TACE showed a trend of better oncological response over DEM-TACE with a longer TTR with a similar adverse events rate, in patients presenting with larger tumors.
B-TACE had a better objective response at 9–12 months and higher TTR after CR at 1-year in comparison to DEM-TACE, with a similar AEs rate, in patients presenting with larger tumors.
These findings suggest a potential advantage of B-TACE for patients with larger tumors.
Link to the full publication: https://doi.org/10.1186/s12876-021-01631-w
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