A comprehensive clinical program

Assessment of ‘safety’ refers to
the side-effect profile and clinical events experienced (eg stroke, myocardial infarction,
unplanned revascularisation). BMS, bare-metal stent; DAPT, dual antiplatelet
therapy; MACCE, major adverse cardiac and cerebral events; MACE, major adverse
coronary events; MCB, major or clinically relevant non-major bleeding; NACE,
net adverse clinical endpoints; OFDI, optical frequency domain imaging; PCI,
percutaneous coronary intervention; STEMI, ST-segment elevation myocardial
infarction; TLF, target lesion failure. * Follow-up will continue up to 5 years
for patients enrolled in Japan.
A remarkable 16 CE marked indications
Consistent good safety* data at 1 year
from controlled clinical trial4 and
routine clinical practice8

For CENTURY II, patient numbers are from the per-protocal analysis at baseline. p=non-significant, unless otherwise stated.
MI, mycordial infarction; ST, stent thrombosis; TV, target vessel.
*Statements on 'safety are based on cardiac death, MI and ST rates in the referenced study,**data on file
Sustained long-term safety* from
controlled clinical trial4
For CENTURY II, patient numbers are from the per-protocal analysis at baseline. p=non-significant, unless otherwise stated.
MI, mycordial infarction; ST, stent thrombosis; TV, target vessel.
*Statements on 'safety are based on cardiac death, MI and ST rates in the referenced study,**data on file
References:
- Stojkovic S et
al. Fundam Clin
Pharmacol
2014;29:95–105;
- Barbato E et
al. EuroIntervention
2015;11:541–8;
- Saito S et al. Eur Heart J
2014;35:2021–31;
- Wijns W et al. EuroIntervention
2018;14:e343–51;
- Valdes-Chavarri M et
al. EuroIntervention
2019;14:e1836-42;
- Chevalier B et al. Circ Cardiovasc Interv
2017;10:pii:e004801;
- Mohamed et al. EuroIntervention
2020;16:603-612
- Roffi M. Presented at
PCR e-course 2020;
- MASTER DAPT trial. Available at
https://clinicaltrials.gov/ct2/show/NCT03023020;
- Frigoli E et
al. Am Heart J
2019;209:97-105
- Model U-SES trial. Available at
https://clinicaltrials.gov/ct2/show/NCT02837003;
- Kozuma K et
al. Circ J
2020;85:19-26