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LifePearl® microspheres are designed to actively absorb drugs into their matrix2

  • 37.5 mg of Doxorubicin per 1 ml of LifePearl® microspheres
  • 5mg of Idarubicin per 1ml of LifePearl® microspheres
  • 25mg of Epuribicin per 1ml of LifePearl® microspheres
  • 50.0 mg of Irinotecan per 1 ml of LifePearl® microspheres


LifePearl® has a tight calibration which may lead to a more targeted embolisation

​Diameter distribution histogram of doxorubicin-loaded microspheres4​Diameter distribution histogram of irinotecan-loaded microspheres5
Picture1.pngPicture2.png


LifePearl® offers longer time in suspension than:

  • DC Bead and HepaSphere when loaded with Doxorubicin4
  • DC Bead and Tandem when loaded with Irinotecan5

Longer time in suspension allows smoother embolization procedure without the need for interruption to resuspend the microspheres

​Microsphere type​Doxorubicin loaded
Time in suspension (s)
​Irinotecan loaded
Time in suspension (s)
​LifePearl​357±7392±23​
​DC Bead​185±11154±13
​Tandem​504±12​198±19
​HepaSphere​172±20​N/A


LifePearl® loaded with Doxorubicin or Irinotecan offers:

  • A steady, continuous and lasting elution over an extended period of time


​Doxorubicin elution4​Irinotecan elution5
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LifePearl® loaded with Epirubicin and Idarubicin offers:

  • A steady, continuous and lasting elution over an extended period of time6


​Idarubicin elution from LifePearl reaches plateau in approx. 2 hours at 75%​Epirubicin elution from LifePearl reaches plateau in approx. 5 hours at 35%
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Volume of microspheres2 ml
Volume of PBS4 ml


Comparison of loading times with Irinotecan, Doxorubicin, Idarubicin and Epirubicin1,7

LifePearl sizes​75 mg liquid Doxorubicin per 2 ml of microspheres75 mg powder​ Doxorubicin per 2 ml of microspheres​100 mg Irinotecan solution per 2 ml of microspheres10 mg Idarubicin solution per 2 ml of microspheres​​50 mg Epirubicin solution per 2 ml of microspheres
​100 ± 25 µm​1 hour​30 minutes30 minutes​​30 minutes​​1 hour
​200 ± 50 µm​4 hours​30 minutes​30 minutes​30 minutes​​1 hour
​400 ± 50 µm​6 hours30 minutes​​30 minutes​4 hours​1 hour

LifePearl sizesColourItem reference
100 ± 25 μmBlack8LP2S100
200 ± 50 μmYellow8LP2S200
400 ± 50 μmBlue8LP2S400

Please quote above item reference codes when placing an order.

LifePearl is not available for sale in all countries. This information is provided only in respect to markets where this product is approved or cleared.  LifePearl is cleared in US with indications for embolization of hyper vascular tumors and arteriovenous malformations. LifePearl is not approved in Canada. Please contact your Terumo local sales representative for more information.

 

 

Chemoembolization of Hepatocellular Carcinoma with Drug-Eluting Polyethylene Glycol Embolic Agents: Single-Center Retrospective Analysis in 302 Patientshttps://www.terumo-europe.com/en-emea/clinicaldata/chemoembolization-of-hepatocellular-carcinoma-with-drug-eluting-polyethylene-glycol-embolic-agents-single-center-retrospectiveChemoembolization of Hepatocellular Carcinoma with Drug-Eluting Polyethylene Glycol Embolic Agents: Single-Center Retrospective Analysis in 302 Patients​Filipe Veloso Gomes, MBChB, BSc, João A. Oliveira, MD, Mariana Tomé Correia, MD, Nuno Vasco Costa, MD, João Abrantes, MD, Daniel Torres, MD, Pedro Pereira, MD, Ana Isabel Ferreira, MD, José Hugo Luz, MD, Erik Spaepen, MSc, Tiago Bilhim, MD, PhD, and Élia Coimbra, MDHayabusaArticlePage
Chemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded With Doxorubicin for the Treatment of Hepato...https://www.terumo-europe.com/en-emea/clinicaldata/chemoembolization-adopting-polyethylene-glycol-drug-eluting-embolics-loaded-with-doxorubicin-for-the-treatment-of-hepatocelChemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded With Doxorubicin for the Treatment of Hepato...<p>​Aliberti, C., Carandina, R., Sarti, D., Mulazzani, L., Pizzirani, E., Guadagni, S., & Fiorentini, G. (n.d.). Chemoembolization Adopting Polyethylene Glycol Drug-Eluting Embolics Loaded With Doxorubicin for the Treatment of Hepatocellular Carcinoma : American Journal of Roentgenology : Vol. 209, No. 2 (AJR)</p>HayabusaArticlePage
Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinomahttps://www.terumo-europe.com/en-emea/clinicaldata/chemoembolization-with-drug-eluting-microspheres-loaded-with-doxorubicin-for-the-treatment-of-cholangiocarcinomaChemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma<p>​Aliberti, C., Carandina, R., Sarti, D., Pizzirani, E., Ramondo, G., Mulazzani, L., Fiorentini, G. (2017, April)</p>HayabusaArticlePage

 

 

 

 

 

 

LifePearl loading instructions DoxPowderhttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions DoxPowder.pdfLifePearl loading instructions DoxPowder11/03/2018 23:00:00{E79942BA-28F9-4CBD-9E11-B82E1FB26ED9}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions Idarubicinhttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Idarubicin.pdfLifePearl loading instructions Idarubicin11/03/2018 23:00:00{CE196BB4-E5B9-4486-B9BD-9DCC4DA7A6C6}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions Epirubicinhttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Epirubicin.pdfLifePearl loading instructions Epirubicin11/03/2018 23:00:00{32615007-798F-49C0-A3C5-C1430D28915A}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions DoxLiquidhttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions DoxLiquid.pdfLifePearl loading instructions DoxLiquid11/03/2018 23:00:00{59EDE07F-BC02-49E8-BC92-30F1F9807374}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8
LifePearl loading instructions Irinohttps://www.terumo-europe.com/Relevant Product Info/LifePearl loading instructions Irino.pdfLifePearl loading instructions Irino11/03/2018 23:00:00{C577C1E4-7C47-483E-91EA-0B721511EB27}HayabusaArticleDocument77054ba1-476b-4af3-b914-9a049e0b9ba8

1 LifePearl Instructions for Use (January 2018)
2 Data on file. Comparison with Terumo's previously commercialized product. Ref LPMCV-004
3 Data on file. Ref LPBTG-002, LPMCV-003, LPMCV-004. Microvention Inc. Comparison with Terumo's previously commercialized produc
4 Thierry de Baere, et al. An In Vitro Evaluation of Four Types of Drug-Eluting Microspheres Loaded with Doxorubicin. J Vasc Interv Radiol. 2016 Sep;27(9):1425-1431
5 Philippe L. Pereira, et al. An in-vitro evaluation of three types of drug-eluting microspheres loaded with irinotecan Anti-Cancer Drugs: October 2016 - Volume 27 - Issue 9 - p 873–878
Data on file. Comparison with Terumo's previously commercialized product. Ref. TR16-158
Data on file. Ref TR14-286 Microvention Inc. Comparison with Terumo's previously commercialized product

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