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Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapy

20/10/2016 -  

​​Aliberti CCarandina RSarti DMulazzani LCatalano VFelicioli ACoschiera PFiorentini G, Anticancer Res. 2016 Jul;36(7):3515-21.

​Abstract

Background/aim:

Recently, there has been the launch of the new Polyethylene glycol (PEG) drug-eluting beads (LifePearl®) for transarterial chemoembolization. Their innovation is that PEG guarantees more compressibility, elasticity and maximizes beads' suspension time. We applied these beads for hepatic intra-arterial infusion of irinotecan or doxorubicin for the therapy of primary andmetastatic liver cancer.

Patients and methods:

We treated 20 consecutive patients, affected by unresectable primary liver cancer (PLC) or hepaticmetastases (refractory to chemotherapy) using chemoembolization with doxorubicin or irinotecan pre-loaded Lifepearls.

Results:

Tumor response rate was >80% in most patients with 63% of complete and 37% of partial response. We observed no complications during the chemoembolization and no severe general drug-related side-effects.

Conclusion:

Our data suggest that chemoembolization with LifePearl® is efficacious and safe for the treatment of liver cancer as indicated by good tolerability, quality of life and high tumor response.

Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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